Scientists are confident that COVID-19 can cause heart damage. Based on an analysis of national healthcare databases from the United States Department of Veterans Affairs, a new study offers a more detailed look at common post-COVID-19 cardiac issues.
The study found that people who have recovered from COVID-19 are at an elevated risk of developing heart problems within the first year after the disease.
University of California, Los Angeles cardiologist Dr. Gregg C. Fonarow — who was not involved in the study — told Medical News Today, “There was a large spectrum of cardiovascular injury and risks documented.”
The study comes from researchers at Washington University School of Medicine in St. Louis and the Veterans Affairs (VA) St. Louis Health Care System.
The senior investigator is Dr. Ziyad Al-Aly, chief of research and development service at the VA St. Louis Health Care System and clinical epidemiologist at Washington University.
“What we’re seeing isn’t good,” Dr. Al-Aly says. “COVID-19 can lead to serious cardiovascular complications and death. The heart does not regenerate or easily mend after heart damage. These are diseases that will affect people for a lifetime.”
Dr. Richard C. Becker, director of and physician-in-chief at the University of Cincinnati Heart, Lung and Vascular Institute — also not involved in the study — told MNT:
“The observations from the [VA Health System] underscore what is less well appreciated in both the medical community and lay community — that is, the long-term cardiovascular effects that can be serious and even life threatening. The important message is ‘awareness’ and having a well-established follow-up plan in place.”
The study appears in Nature MedicineTrusted Source.
A variety of heart issues
Dr. Al-Aly described to MNT the types of heart damage known to occur after a SARS-CoV-2 infection:
“A broad array of cardiovascular diseases, including cerebrovascular disease, dysrhythmias, ischemic and nonischemic heart disease, pericarditis, myocarditis, heart failure, and thromboembolic disease. The risks were evident even in people who had mild COVID-19 and did not need to be hospitalized during the acute phase of the disease.”
It also appears to be the case, Dr. Al-Aly observes, that COVID-19 does not play favorites when it comes to who might experience postinfection heart problems,
“I would also add that the risks were evident in young [people and older adults], females and males, white people and Black people, people who smoke and people who do not, people with comorbidities — diabetes, hypertension, kidney disease — and people without.”
What may be happening
Dr. Becker explained what might be the cause of so much heart damage,
“The medical community knows that [SARS-CoV-2] infection during its initial or acute phase can cause inflammation of the heart (myocarditis); inflammation of the heart’s covering (pericarditis); heart attacks (myocardial infarction) stemming from the stress of infection, low blood oxygen levels, or blood clots forming in the coronary arteries; and heart failure.”
Those blood clots may provide an important clue, Dr. Becker noted:
“There is reason to believe that blood clots, [or thrombosis], causing heart attacks and strokes in COVID-19 have unique and distinct characteristics. Specifically, they include a much higher proportion of specific subsets of white blood cells than would be seen in other settings. The COVID-19 blood clot theory is starting to take shape. Research is ongoing to understand a specific cause and optimal prevention and treatment.”
“Our observation is that COVID-19-associated pericarditis can be more difficult to treat compared with other virus-associated pericarditis, and recurrence appears to be more common,” Dr. Becker added.